Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page,

NFL Week 13 odds, picks, predictions, TV and streaming information for Sunday Night Football game between the San Francisco 49ers and Buffalo Bills.

The 49ers were coming off a Super Bowl appearance and the Bills had all the look of a team that would regress. But the season hasn't really gone the way people predicted for either team. This week, Buffalo hopes to clinch a fifth-straight AFC East title,

Find out how these three teams can punch their postseason ticket with over a month to go in the regular season.

It’s Week 13 in the NFL, and the Buffalo Bills have a chance to secure their fifth consecutive AFC East title, setting a new franchise record. For this to happen, Buffalo (9-2) first needs the Miami Dolphins (5-6) to fall to the Green Bay Packers on Thanksgiving night. Then, the Bills must defeat the San Francisco 49ers on Sunday Night Football.

The Bills are off to their best start since 1993, and could punch their ticket to the 2024 playoffs as early as this week.