The Indianapolis Colts need everything they can to defeat the Detroit Lions at Lucas Oil Stadium tomorrow afternoon. While there are plenty of players to highlight in this cross-conference battle, all Colts fans' eyes will be on quarterback Anthony Richardson and whether he can build on a solid week 11 victory.

The Indianapolis Colts are coming off an encouraging performance and win in Week 11 over the Jets. However, building upon that becomes a lot more difficult with the Detroit Lions awaiting the Colts in Week 12. The Lions will enter this game at 9-1 on the ...

The Indianapolis Colts are coming off a win over the Jets in what was a highly encouraging performance from Anthony Richardson. However, awaiting them in Week 12 are the red-hot Lions. Detroit will enter this game at 9-1 and have consistently been the most

Any potential success for the Colts begins with the run game on both sides of the ball. The defense has to find a way to contain Jahmyr Gibbs and David Montgomery, while the offense has to be able to pick up yards on the ground to avoid becoming one-dimensional.

Preview the Week 12 matchup between the Detroit Lions and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.

The Detroit Lions make the short trip to Indianapolis in Week 12 to face the Colts at Lucas Oil Stadium. It’s a step up in AFC South competition for the Lions, who waxed the Jaguars 52-6 a week ago.

Indianapolis Colts quarterback Anthony Richardson has to have a Herculean performance to defeat the Detroit Lions.

As the Colts cling to their playoff hopes, who else should you be rooting for this week to help Indianapolis out?