The San Francisco 49ers will be without their starting quarterback and their best defensive player when they visit the Green ...

The San Francisco 49ers will be missing two of their best players in their must-win matchup against the Green Bay Packers ...

The San Francisco 49ers fell to 5-6 on the season in losing to the Green Bay Packers on Sunday. Top takeaways with Brock ...

Jaire Alexander, Edgerrin Cooper, Brock Purdy and Nick Bosa were all ruled out Friday; 49ers LT Trent Williams joins them on ...

Kyle Shanahan made a stunning revelation involving the health of Nick Bosa following the loss to the Seahawks.

The 49ers have allowed 222 points, or 22.2 points per game, tied for 16th. Last year, the defense allowed 298 points, or 17.5 ...

The San Francisco 49ers are expecting to get star tight end George Kittle back this week for a key game against Green Bay, ...

This just isn't the 49ers' week. They have now been dealt the worst-case scenario with Nick Bosa's status against the Packers ...

Brandon Allen will start in place of an injured Brock Purdy when the 49ers (5-5) also have to play without Nick Bosa on ...

San Francisco 49ers head coach Kyle Shanahan has offered an update on the injuries to Nick Bosa and Brock Purdy.

San Francisco 49ers tight end George Kittle confidently declared on Wednesday that he will suit up for this weekend's game ...

The stars' value has never been more pronounced, as the 49ers bumbled their way to one of the worst losses in the ...