The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

The two strands of DNA, although chemically equivalent, are replicated and repaired asymmetrically. Insights into the persistence of DNA damage show how strand-specific interactions shape the ...

Drs Ursula A. Matulonis and Joyce F. Liu discuss targeting DNA damage and repair and replication stress in endometrial cancer. Drs Ursula A. Matulonis and Panagiotis A. Konstantinopoulos discuss ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

McMillan’s lab aims to further characterize the role of SSB as a first responder and the proteins that are part of the crisis ...

A new critical review in Molecular Biology Reports systematically compares the biochemical, cellular, and genome-wide assays ...

If severe DNA damage is not repaired, the consequences for the health of cells and tissues are dramatic. A study led by researchers at Goethe University Frankfurt, part of the Rhine-Main University ...

Although DNA is tightly packed and protected within the cell nucleus, it is constantly threatened by damage from normal metabolic processes or external stressors such as radiation or chemical ...

Genome instability can cause numerous diseases. Cells have effective DNA repair mechanisms at their disposal. A research team has now gained new insights into the DNA damage response. Whenever cells ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing the entire repair sequence as it unfolds. Instead of freezing cells at ...

Every time a cell divides, it must copy its entire genome so that each daughter cell inherits a complete set of DNA. During that process, enzymes known as polymerases race along the DNA to copy its ...

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4). These bundles form in guanine-rich regions across the genome, including ...