Here we have designed and synthesized ligands that specifically bind with high affinity (K d = 53 nM) to the guanine (G)–guanine mismatch, one of four types of single-nucleotide polymorphism (SNP).

Chemical structure of guanine, showing its double-ring purine structure and the functional groups involved in hydrogen bonding with cytosine. (Image: Public Domain) Guanine has the chemical formula ...