A new conditional knockout mouse model shows that loss of the epigenetic regulator Tet2, combined with aging and a reshaped ...

The study, published in GeroScience, investigated mutations in DNMT3A and TET2, the two most common mutations in clonal ...

A new framework in the Journal of Translational Medicine defines when blood-cell clones should be treated as sequencing ...

Nagase and colleagues recently described a mouse model of CHIP and its transformation to a model of acute myeloid leukemia. 5 An Asxl1 mutation causes CHIP (Panel A) and leads to epigenetic ...

The decrease in the incidence of cardiovascular disease and the improved prognosis in persons with a diagnosis of cardiovascular disease are due, in part, to the development of new treatments based on ...

A research team led by Professor Megumu K. Saito (Department of Clinical Application) examined the dynamic transcriptional and epigenetic landscape during definitive hematopoiesis and revealed the non ...

Share on Pinterest A cellular process that affects blood cells emerges as a new risk factor for atherosclerosis. Image credit: Mangkelin/Getty Images. Their two recent studies have uncovered new ...

Phase I Dose-Escalation Study of Once Weekly or Once Every Two Weeks Administration of High-Dose Sunitinib in Patients With Refractory Solid Tumors The article by Boettcher et al entitled “Clonal ...

The immune system is one of the most complex and fascinating networks in the human body. Comprised of cellular and humoral components, it not only protects us against external intruders such as ...

To the known risk factors for cardiovascular disease - high blood pressure, high cholesterol, diabetes, overweight and obesity, smoking, and physical inactivity - a new one has to be added: clonal ...