The intestinal epithelium, the largest interface between the host and environment, regulates fluxes of ions and nutrients and limits host contact with the massive load of luminal antigens. Local ...

Tight junctions are intercellular adhesion complexes in epithelia and endothelia that control paracellular permeability. This paracellular diffusion barrier is semipermeable: it is size- and ...

The use of ion chromatography with amperometric detection for simple and reliable determination of lactulose and mannitol in urine is described in this article. Diagnosis of the leaky gut syndrome and ...

A method for the quick and reliable analysis of size-selective paracellular tracer diffusion using fluorescent dextrans of different molecular weights is described. The assay could be easily adapted ...

Researchers have identified a previously unknown mechanism by which the kidney precisely controls calcium excretion. The ...

PNAS is the world's most-cited multidisciplinary scientific serial. It publishes high-impact research reports, commentaries, perspectives, reviews, colloquium papers, and actions of the Academy. In ...