Three decades ago, cancer biologists embraced an elegant idea known as the sphingosine rheostat: a molecular dial inside ...

Synthetic biochemistry seeks to engineer complex metabolic pathways for chemical conversions outside the constraints of the cell. Establishment of effective and flexible cell-free systems requires the ...

St. Jude Children's Research Hospital scientists have determined how a protein's disordered region serves as a molecular rheostat to help regulate cell survival. The survival drama is played out ...

Cambridge, Massachusetts-based biotech company Rheostat Therapeutics announced it has raised $23 million in Series A funding to develop potential treatments for neurodegenerative diseases, cognition, ...

Although drugs that target the brain's serotonin system are in wide use for treating depression, the basic biological mechanism by which they help alleviate symptoms is poorly understood. Now, new ...

Researchers have found a switch that regulates the activity of HNF1A, a gene that causes diabetes. The study highlights potential new vulnerabilities in the disease and could lead to the development ...