Nature

Single-strand conformation polymorphism analysis using capillary array electrophoresis for large-scale mutation detection

This protocol describes capillary array electrophoresis single-strand conformation polymorphism (CAE-SSCP), a screening method for detection of unknown and previously identified mutations. The method ...
Nature

Exon-Scanning Mutation Analysis of the ATM Gene in Patients with Ataxia-Telangiectasia

Using a polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) assay, which amplifies individually all coding exons of the ATM gene deficient ataxia-telangiectasia (A-T), we have ...
ascopubs.org

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases.

p53: from molecular mechanisms to prognosis in cancer. Forty-eight patients with newly diagnosed BL or L3 ALL, most of whom were treated with very intensive regimens, including early CNS disease ...
ascopubs.org

Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia.

Escalating systemic exposure of continuous infusion topotecan in children with recurrent acute leukemia. Cells from 79 pediatric ALL patients were investigated for inactivation of the p15INK4B and ...