Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children's Research Hospital are exploring how a type ...

New research shows that Alzheimer's disease disrupts androgen receptor signaling in the male brain by dismantling the ...

Premature bolting—the untimely switch from leaf production to flowering—poses a major threat to the yield and quality of Brassica campestris, a leafy vegetable widely cultivated across Asia. Now, ...

New research has uncovered more about the complexity of human gene regulation by identifying certain sequences of proteins called transcription factors that bind to DNA and regulate the expression of ...

Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in ...

A single transcription factor may be enough to rewrite the identity of a cell. In a study published in Cellular and Molecular Life Sciences, researchers at Mie University in Japan report that PU.1, a ...

A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, according to a recent study published in ...

Bioengineers have developed a generalizable method to address 'off-target' binding, a significant problem in the field of synthetic biology. Taking a cue from nature, the researchers showed they could ...

A new study has uncovered new genetic rules that determine how CD8 “killer” T cells choose between becoming long-lasting, protective immune cells or slipping into exhausted, dysfunctional states.

Scientists studied how the epigenetic landscape influences the binding of pioneer transcription factors, affecting access to DNA. Like thread tightly wrapped around a spool, DNA is wrapped around ...