Figure 1: Domain structure of dynamin showing mutants of the GTPase domain. Figure 2: Uptake of biotinylated transferrin (green staining) into COS-7 fibroblasts, transiently overexpressing dynamin or ...

Figure 1: smFRET–TIRF microscopy reveals dynamic movements of the SRP–FtsY complex on the SRP RNA. Figure 2: The distal site of SRP RNA is crucial for GTPase activation and protein targeting. Figure 3 ...

UCSF scientists have discovered how to target a large family of molecular switches called GTPases that are involved in myriad diseases, from Parkinson’s to cancer, and have long been thought to be ...

The Transcreener GTPase Assay Kit relies on direct detection of GDP produced by GTPases during GTP hydrolysis. The direct detection approach is a novel method to quantify activity of GTPases and their ...

For most of us who haven’t entirely slept through biology classes, it’s probably no secret that ATP (adenosine triphosphate) is the compound which provides the energy needed for us to move our muscles ...

Erasca Inc. has described GTPase KRAS (G12D mutant) and/or KRAS (G12V mutant) inhibitors reported to be useful for the treatment of cancer.

Although there are more than 150 guanosine triphosphate (GTP)–binding proteins, or GTPases, only the GTPase KRas G12C has proved susceptible to small-molecule drugs. That’s because it’s tough to find ...

GPCRs are by far the most extensively validated class of therapeutic targets, and there remains tremendous potential for targeting new receptors and their downstream effectors. GPCRs at the cell ...

Université de Montréal has disclosed GTPase KRAS G12D mutant inhibitors reported to be useful for the treatment of cancer, inflammatory disorders and immunological disorders.