George injured his knee when Memphis’ Desmond Bane inadvertently landed on George’s foot while both went for a rebound. It's the same knee injury that kept him out to start the season.

Just as Tyrese Maxey returned, Paul George was forced to leave Wednesday’s game against the Grizzlies and did not return

The Sixers then announced in the fourth quarter that George will not return due to a left knee hyperextension. For those paying attention at home, that is the same left knee that George had an issue with in the preseason that kept him out for a few weeks and caused him to miss the first five games of the season.