A new study of 450 colorectal cancer patients has delivered some of the clearest evidence yet that mutations in two DNA proofreading genes, POLE and POLD1, can identify which patients are most likely ...
DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...
Atezolizumab (A) plus pertuzumab/trastuzumab/hyaluronidase (PHESGO) in patients (pts) with solid tumors with ERBB2 alterations (alt): Results from the Targeted Agent ...
Translesion synthesis polymerases efficiently incorporate nucleotides opposite DNA lesions. Pol ι, for example, bypasses minor-groove and exocyclic purine adducts. Conventional X-ray crystallography ...
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