Researchers have identified a conserved small GTPase complex that acts as a molecular gate controlling regulated secretion in ...

Researchers have discovered that Giardia lamblia runs an ATG8-independent autophagy-like pathway regulated by its sole Rho ...

The GTPase switch is a versatile molecular device used by many proteins, such as the small GTPases, to regulate an astounding number of functions. Although the basics of the guanine nucleotide cycle ...

Discover the latest articles and news in related subjects. To address the timing of Nug2 recruitment to pre-60S particles in comparison to Rea1, Rsa4 and the Rix1–Ipi1–Ipi3 complex, we used a ...

UCSF scientists have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases from Parkinson's to cancer and have long been thought to be ...

Scientists at the University of California, San Francisco (UCSF), have discovered how to target a class of molecular switches called GTPases that are involved in a myriad of diseases—from Parkinson’s ...

The GTPases constitute a very large protein family, whose members are involved in the control of cell growth, transport of molecules, synthesis of other proteins, etc. Despite the many functions of ...

Drugs for the K-Ras oncogene inspire an approach for targeting the GTPases, a family of enzymes whose dysfunction can lead to Parkinson's and many other diseases. UCSF scientists have discovered how ...

Astellas Pharma Inc. has divulged proteolysis targeting chimera (PROTAC) compounds acting as GTPase KRAS (G12D mutant) degradation inducers reported to be useful for the treatment of pancreatic cancer ...

Kumquat Biosciences Inc. has identified GTPase KRAS and KRAS (G12D mutant) inhibitors reported to be useful for the treatment of cancer, particularly solid tumors and hematological cancer.

UCSF scientists have discovered how to target a large family of molecular switches called GTPases that are involved in myriad diseases, from Parkinson’s to cancer, and have long been thought to be ...