Between 10 to 15% of all genetic diseases have the same underlying cause: a nonsense mutation. 1 This type of mutation results from a stop codon in the middle of a gene sequence, which terminates ...

There is no cure for Duchenne muscular dystrophy (DMD), in which affected individuals have muscle weakness and heart and respiratory issues. But for some, a new kind of gene therapy is showing ...

(A) Suppressor tRNA readthrough strategy. Natural tRNAs with engineered anticodons are charged with canonical amino acids to enable readthrough of the premature termination codon (PTC). (B) Unnatural ...

For decades, biology students have learned one rule about the genetic code that supposedly has no exceptions: three specific DNA sequences act as stop signs, telling the cell’s protein-building ...

Gene editing can repair mutations that prematurely halt protein synthesis, resulting in incomplete peptides that cause various diseases. However, other approaches achieve the same effect without ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian cells, researchers from Peking University led by Chen Peng from College of ...