Researchers have built the first R-loop-related gene signature for esophageal squamous cell carcinoma, identifying BRIX1, ...

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

DNA can be more than just a double helix. When four strands are folded into a compact bundle, they form a G-quadruplex (G4).

Cancer cells that carry ecDNA appear to rely on specialized repair machinery to keep these fragile DNA circles intact. Credit ...

Every embryo begins with a race against time. Primordial germ cells, the rapidly dividing precursors that ultimately give rise to eggs and sperm, must copy and safeguard their entire genome over and ...

The Okazaki Fragments That Solved the Mystery of DNA Replication1. The Mystery That Could Not Be Solved by the Discovery of ...

Hour Clock"?When studying biology, you encounter mysterious numbers.In human cultured cells, there are cases where the time ...

At the scale of individual cells, the human body is constantly in motion. Every second, millions of cells divide, particularly in tissues such as the bone marrow, intestine and skin; neurons and heart ...

The ATR–ATRIP kinase complex safeguards genome integrity by coordinating cellular responses to DNA damage and replication stress. Two recent cryo-EM studies resolve the structural basis of ATR–ATRIP ...

Two mysterious human relatives left their genetic footprints in the modern human genome alongside the DNA of Neanderthals and Denisovans, underscoring the fact that our ancestors interbred with many ...

Reconstitution of actomyosin networks in cell-sized liposomes dissects distinct mechanisms of membrane blebbing and symmetry breaking Maintenance of genome integrity during DNA replication is ...

FSU College of Medicine’s Daniel Betancourt (left) and Zucai Suo (right) worked with a research team to publish findings that offer new insights into DNA repair and its role in cancer prevention and ...