Congenital DM1 is the most severe and earliest occurring form of myotonic dystrophy. It occurs when a mother, who often is not aware she has DM1, passes the mutation that causes DM1 onto her child.

DM1 is the most common form of myotonic muscular dystrophy diagnosed in children, with a prevalence ranging from 1 per 100,000 in Japan to 3–15 per 100,000 in Europe. [13]

Research suggests that, in DM1, there may be abnormalities in the parts of the brain that determine the rhythm of sleeping and waking, making excessive daytime sleepiness a barrier to full participation in …

Dec 12, 2022 · There are two main forms of myotonic dystrophy: Myotonic dystrophy type 1 (DM1), also known as Steinert disease. DM1 has four types: classic, mild, congenital and childhood. Myotonic …

Myotonic dystrophy type 1 (DM1) is a genetic, multisystem condition causing progressive muscle weakness, stiffness, and complications in the heart, lungs, and digestion. Learn about symptoms, …

Nov 14, 2024 · Classic DM1 is characterized by muscle weakness and wasting, myotonia, cataract, and often cardiac conduction abnormalities; adults may become physically disabled and may have a …

Mar 19, 2024 · There are two types of myotonic dystrophy: DM1 and DM2, and different genetic mutations cause each type. These mutations affect the muscle structure, leading to weakness and …

DM1 test via molecular genetic testing is the first line of investigation for anyone suspected of having DM1. More than 50 CTG repeats in the 3’ untranslated region of the DMPK gene on chromosome 19 …

Nov 18, 2024 · Type 1 (DM1) is the most common form of muscular dystrophy in adults, affecting about 1 in 2,100 individuals, and is a multisystemic condition.

Type 1 DM (DM1), long known as Steinert disease, occurs when a gene on chromosome 19 called DMPK contains an abnormally expanded section located close to the regulation region of another …