Hypoxia-inducible factor - Wikipedia
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreases in available oxygen in the cellular environment, or hypoxia. [1][2] They also respond to instances of …
The Distinct Role of HIF-1α and HIF-2α in Hypoxia and ... - PubMed
May 4, 2025 · The current review highlights the different roles and regulatory mechanisms of HIF-1α and HIF-2α isoforms, focusing on their involvement in cell metabolism and the multi-step …
Hypoxia Inducible Factors (HIFs) - Bio-Techne
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreased oxygen level in the cellular environment. Various isoforms and splice variants have been identified and their …
Hypoxia Inducible Factor - an overview | ScienceDirect Topics
Hypoxia-inducible factor (HIF) is defined as a key transcription factor that mediates physiological responses to low oxygen levels by regulating the expression of genes involved in processes …
HIF Protein: Role in Oxygen Sensing, Health, and Disease
Jul 20, 2025 · Hypoxia-Inducible Factor, or HIF, is a group of proteins that functions as a master switch within our cells, responding to the availability of oxygen. This system allows organisms …
Targeting hypoxia-inducible factors: therapeutic opportunities and ...
Dec 20, 2023 · Hypoxia-inducible factors (HIFs) are highly conserved transcription factors that are crucial for adaptation of metazoans to limited oxygen availability. Recently, HIF activation and …
HIF-1 and HIF-2 in cancer: structure, regulation, and therapeutic ...
Jan 18, 2025 · In this review, we describe an overview of the structure, expression, and DNA binding of the HIF-1 and HIF-2 complexes. We use the terminology ‘canonical’ to describe …
Action Sites and Clinical Application of HIF-1α Inhibitors
HIF-1 is the only transcription factor that has been found to be active under hypoxia, and is also the main nuclear transcription factor that mediates the adaptive response to hypoxia in …
Hypoxia Inducible Factors - Novus Biologicals
Hypoxia-inducible factors (HIFs) are transcription factors that respond to decreased oxygen level in the cellular environment. Various isoforms and splice variants have been identified and their …
The Hypoxia-Inducible Factor Pathway (HIF) | Haase Lab
HIF-1 and HIF-2 are the most extensively studied HIF transcription factors and facilitate oxygen delivery and adaptation to hypoxia by regulating a wide spectrum of cellular and tissue hypoxia …