The Secreted frizzled-related protein (SFRP) family consists of five secreted glycoproteins in humans (SFRP1, SFRP2, SFRP3, SFRP4, SFRP5) that act as extracellular signaling ligands.

One mode of signaling pathway regulation occurs at the level of extracellular antagonists that interact with ligands and prevent signaling. The secreted Frizzled-related proteins (sFRP) were …

Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-like cysteine-rich domain. This domain enables them to bind to Wnt ligands or frizzled (FzD) …

Aug 6, 2019 · Secreted frizzled-related proteins (SFRPs) are mainly known for their role as extracellular modulators and tumor suppressors that downregulate Wnt signaling.

Dec 14, 2008 · Secreted Frizzled-related proteins (sFRPs) are signalling molecules well-known as antagonists of the Wnt pathway, but recent studies indicate that they may have additional …

Jul 17, 2025 · SFRP1 (Secreted Frizzled Related Protein 1) is a Protein Coding gene. Diseases associated with SFRP1 include Osteoporosis and Chronic Closed-Angle Glaucoma. Among its …

Oct 1, 2023 · Secreted frizzled-related proteins (SFRPs) are extracellular inhibitors of Wnt signaling that act by binding directly to Wnt ligands or Frizzled receptors. SFRPs can act as …

Secreted frizzled-related protein 2 is a protein that in humans is encoded by the SFRP2 gene. [5][6] This gene encodes a member of the SFRP family that contains a cysteine -rich domain …

Secreted frizzled related protein (SFRP) family members are antagonistic inhibitors of the Wnt signaling pathway, and they were recently found to be involved in the pathogenesis of a …

Nov 5, 2024 · We have uncovered that the MSCs that lack MED1 subunit of the Mediator transcriptional coregulatory complex do not sufficiently support hematopoietic stem/progenitor …