The TP53 gene is the most frequently mutated gene (>50%) in human cancer, indicating that the TP53 gene plays a crucial role in preventing cancer formation. [5]

Dec 19, 2025 · The TP53 gene helps prevent cancer by repairing DNA or causing cell death when DNA is too damaged. Mutations in the TP53 gene are found in over 50% of cancer cases and can lead to …

The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor suppressor, which means that it regulates cell division by keeping cells from growing …

Extensively studied over the past four decades, the TP53 gene has emerged as a pivotal watchman in cellular defense and a key factor in cancer biology. TP53 is the most frequently mutated gene in …

Nov 14, 2025 · TP53 (Tumor Protein P53) is a Protein Coding gene. Diseases associated with TP53 include Li-Fraumeni Syndrome and Osteogenic Sarcoma. Among its related pathways are Toll Like …

Explore functional and structural data and frequency statistics of all possible single nucleotide substitutions in TP53 exonic sequences, other variants reported in human samples, and validated …

Sep 7, 2025 · People who are born with changes—called mutations—in the TP53 gene have a syndrome known as Li-Fraumeni syndrome and an increased risk for many different types of cancer. …

Oct 23, 2024 · It appears that the TP53 gene has emerged as a victim of its own evolutionary past that shaped its structure and function towards a pluripotent tumor suppressor, but came with an increased...

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the …

Also called p53 gene and tumor protein p53 gene. A gene that makes a protein that is found inside the nucleus of cells and plays a key role in controlling cell division and cell death. Mutations (changes) in …