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Propofol is the most widely used intravenous anesthetic in modern medicine for good reason. It works primarily as a positive allosteric modulator of GABA-A receptors, opening chloride channels to produce rapid unconsciousness within 30 to 45 seconds. Because it is highly lipid soluble, it is formulated in an oil-in-water emulsion containing soybean oil and egg lecithin, giving it that characteristic white milk appearance. Reduces blood pressure, blunts airway reflexes, and wears off clean within
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Administering low-dose intravenous ketamine transforms multimodal general anesthesia by targeting central pain pathways before surgical stimulation begins. Ketamine functions as a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist, dampening dorsal horn wind-up and preventing acute central sensitization (Peltoniemi et al., 2016). When combined synergistically with gamma-aminobutyric acid (GABA) receptor agonists like propofol, it produces reliable hypnotic depth and somatic analgesia
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Short videos

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Propofol review! "The milk of amnesia" #nursing #clinical #icu #nurse
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YouTubeSimpleNursing
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